Poster presentation summary
Advances in coupling technologies, new release structures, and multi-mechanism payloads have driven the development of the ADC field. However, further improvements in drug delivery and overcoming drug resistance are urgent challenges for the next generation of ADC drugs. Mabwell has independently developed IDDC™ technology and a new payload, Mtoxin™. Research results show that:
1. DARfinity™ produces site-specific binding drugs based on DAR 4 (DAR 4 ≥ 95%).
2. IDconnect™ improves plasma stability and payload transfer efficiency of ADC drugs (40% increase over control group).
3. LysOnly™ technology enhances the tumor-specific release ability of ADC drugs and reduces off-target effects.
4. Mtoxin™ has excellent tumor penetration, bystander killing efficacy, and anti-multidrug resistance.
5. ADC medicines developed based on IDDC™ and Mtoxin™ have excellent pharmacodynamic and safety properties, especially in multidrug-resistant models of DXd resistance.
summary
IDDC™ is a clinically validated site-specific binding technology with superior uniformity, efficacy, and safety benefits. Additionally, the novel payload Mtoxin™ (MF6) possesses excellent pharmacodynamics, bystander killing efficacy, and anti-multidrug resistance.
Novel ADC drugs developed based on the IDDC™ platform
The IDDC™ platform has been validated with multiple drugs under investigation.
9MW2821 – Novel Nectin 4-targeted ADC:
9MW2821, indicated for urothelial cancer, is the first Nectin-4 ADC developed by a Chinese company to enter Phase III clinical trials, and the second in the world in terms of progress. 9MW2821 is also the world's first therapy targeting the same target and has published clinical efficacy data for the cervical cancer and esophageal cancer indications. has been granted Fast Track designation by US Food and Drug Administration (FDA) Used to treat advanced, recurrent, or metastatic esophageal squamous cell carcinoma.
7MW3711 – New B7-H3 target ADC:
7MW3711 is in clinical trials in advanced solid tumors.
9MW2921 – New Trop-2 Target ADC:
9MW2921 is undergoing clinical trials in advanced solid tumors.
About Mabwell
Mabwell (688062.SH) is an innovation-driven biopharmaceutical company serving the entire pharmaceutical value chain. We meet the world's medical needs by providing more effective and accessible treatments and innovative medicines. Since 2017, an advanced R&D system has been established covering target discovery, early detection, drug potential, preclinical, clinical research, and manufacturing transformation. Mabwell has 14 pipeline products at various stages, including his 10 new drug candidates and 4 biosimilars, based on a world-class, cutting-edge R&D engine . The company focuses on therapeutic areas such as oncology, autoimmune diseases, metabolic diseases, ophthalmology and infectious diseases. Two of these products have been approved and commercialized, two have submitted for MA approval, and three are important therapeutic agents. ordeal. Additionally, we implemented one “national major science and technology special project.”Important new drug development”, participating in two projects of the national key research and development program, and several provincial and local government science and technology innovation projects. Mabwell's Taizhou factory has strong in-house manufacturing capabilities that comply with international GMP standards regulated by NMPA, FDA, and EMA and has passed the EU. Large scale manufacturing facility located in QP Audit.
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Source Mabwell
