Researchers from the University of Cambridge, the University of Oxford and the California Institute of Technology have jointly developed a new vaccine technology that has been shown to provide protection against a wide range of coronaviruses, including those that have not yet emerged.
was announced on natural nanotechnology Funded by the Biotechnology and Biological Sciences Research Council, this new 'proactive vaccinology' approach aims to develop vaccines for future outbreaks before disease-causing pathogens emerge. It is an object.
Most conventional vaccines use a single antigen to train the immune system to target a single specific virus, so they cannot protect against a variety of existing coronaviruses or newly emerging pathogens. There is a possibility.
Based on previous research conducted by the University of Oxford and the California Institute of Technology, the new all-in-one “quartet nanocage” vaccine is designed to train the body to recognize specific regions of eight coronaviruses, including SARS-CoV-1, SARS. works to train the immune system. -CoV-2 and several other viruses are circulating in bats and can cause a pandemic in humans.
For example, even though it does not contain the SARS-CoV-1 coronavirus, the vaccine still elicits an immune response against that virus.
The vaccine is based on a nanoparticle structure, which is spheres of proteins held together by strong interactions, and showed a broadly increased immune response in mice pre-immunized with SARS-CoV-2.
Professor Mark Howarth, from the University of Cambridge's School of Pharmacy, said: “We don't need to wait for a new coronavirus to emerge.''
He added: “We know enough about coronaviruses and the different immune responses to them that we can now start developing protective vaccines against unknown coronaviruses.”
The technology, which is much simpler in design compared to other vaccines, could be used to develop vaccines to protect against many other health problems, and the vaccine could enter Phase 1 clinical trials in early 2025. It's planned.
Rory Hills, Postgraduate Research Fellow, School of Pharmacy, University of Cambridge, said: [was] The goal is to develop a vaccine that will protect us from the next coronavirus pandemic and be ready before the pandemic begins.
“We have developed a vaccine that provides protection against a variety of coronaviruses, including those that are still unknown.”
