UQ researchers use new dosing technique to enhance antibiotic treatment in the ICU

Researchers at the University of Queensland used dosing software to boost the effectiveness of antibiotics in patients being treated for sepsis in intensive care.

Professor Jason Roberts, from the UQ Clinical Research Center and co-senior author of the study, said the technology trialled in the DIRECT study allowed patients to receive effective antibiotics in half the usual time, resulting in faster recovery and improved quality. It said it would lead to higher care, lower costs and increased hospital bed availability. hospital.

“We found that we can dramatically improve the accuracy and quality of care provided to adults and children, meaning shorter ICU stays and faster healing,” Professor Roberts said. .

“We can quickly identify the bacteria causing serious infections and apply a personalized dosing approach to ensure each patient receives the most effective dose for their needs. I achieved this by doing this.

“The team used Bayesian dosing software in four adult and pediatric ICUs, resulting in estimated medical cost savings of $12,000 per patient in some groups.”

The trial was unusual in that it included children and involved collaborators from four major Brisbane hospitals.

UQCCR principal investigator and co-senior author Associate Professor Adam Irwin said the improved accuracy of infectious disease treatment was a great achievement.

“In this study, clinicians in pediatric and adult intensive care facilities alike applied medication software recommendations with confidence. This meant that critically ill children and adults benefited from the results. “I do,” Dr. Irwin said.

The study included ICU physicians and nurses, pharmacists, infectious disease physicians, microbiologists, and health economics experts.

This research highlights our strong commitment to providing the best possible care for Queenslanders.

We hope that with further funding we will be able to demonstrate the value of this therapeutic approach to a wider international audience. ”

Professor Adam Irwin

DIRECT was funded by MRFF Rapid Applied Research Translation Program Grants administered through Health Translation Queensland and conducted at the Hurston Infectious Disease Research Institute in collaboration with Metro North Health, Queensland Children's Hospital and Metro South Health.

The study is published in the journal Intensive Care Medicine.